|
|
gamma-Glu-L-Cys + NADP+ <=> H+ + bis-gamma-glutamylcystine + NADPH
|
1.8.1.13
bis-gamma-glutamylcystine reductase
|
–
|
| |
BRENDA:
BR36930
KEGG:
R02742
MetaCyc:
1.6.4.9-RXN
|
|
|
|
L-homocystine + glutathione <=> GSSG + L-homocysteine
|
1.8.4.1
glutathione---homocystine transhydrogenase
|
–
|
| |
BRENDA:
BR37027
KEGG:
R01110;
R01292
MetaCyc:
1.8.4.1-RXN
|
|
|
|
trypanothione + NADP+ <=> trypanothione_disulfide + NADPH + H+
|
1.8.1.12
trypanothione-disulfide reductase
|
–
|
| |
BRENDA:
BR37012
KEGG:
R03821
MetaCyc:
1.8.1.12-RXN
SABIO-RK:
3577
|
|
|
|
dehydroascorbate + glutathione <=> ascorbate + GSSG
|
1.8.4.9
adenylyl-sulfate reductase (glutathione)
1.8.5.1
glutathione dehydrogenase (ascorbate)
|
–
–
|
| |
BRENDA:
BR36971
KEGG:
R01108
MetaCyc:
1.8.5.1-RXN
SABIO-RK:
1372
|
|
|
|
GSSG + CoA <=> glutathione + CoA-glutathione
|
1.8.4.3
glutathione---CoA-glutathione transhydrogenase
|
–
|
| |
BRENDA:
BR37024
KEGG:
R01111
MetaCyc:
1.8.4.3-RXN
|
|
|
|
6-phosphogluconate + NADP+ <=> 6-phospho-2-dehydro-D-gluconate + NADPH + H+
|
1.1.1.43
phosphogluconate 2-dehydrogenase
|
–
|
| |
BRENDA:
BR29306
KEGG:
R02034
MetaCyc:
1.1.1.43-RXN
SABIO-RK:
490
|
|
|
|
ATP + glutathione + spermine <=> ADP + phosphate + Glutathionylspermine
|
6.3.1.9
trypanothione synthase
|
–
|
| |
KEGG:
R08352
|
|
|
|
glutathione + an_L-amino_acid <=> Cys-Gly + 5-L-glutamyl-L-amino_acid
|
2.3.2.2
gamma-glutamyltransferase
|
–
|
| |
KEGG:
R01262
|
|
|
|
an_(L-cysteinylglycine)-S-conjugate + H2O <=> an_L-cysteine-S-conjugate + glycine
|
3.4.11.1
leucyl aminopeptidase
3.4.11.2
membrane alanyl aminopeptidase
3.4.11.23
PepB aminopeptidase
3.4.13
3.4.13.23
cysteinylglycine-S-conjugate dipeptidase
|
–
–
–
–
–
|
| |
BRENDA:
BR52945
KEGG:
R04951;
R12514
|
|
|
|
RX + glutathione <=> acceptor + R-S-glutathione
|
2.5.1.18
glutathione transferase
2.5.1.75
tRNA dimethylallyltransferase
|
–
–
|
| |
BRENDA:
BR47501
KEGG:
R03522
SABIO-RK:
3310
|
|
|
|
Homotrypanothione + NADP+ <=> Homotrypanothione_disulfide + NADPH + H+
|
1.8.1.12
trypanothione-disulfide reductase
|
–
|
| |
KEGG:
R08357
|
|
|
|
glutathionylspermidine + H2O <=> glutathione + spermidine
|
3.5.1
3.5.1.78
glutathionylspermidine amidase
|
–
–
|
| |
BRENDA:
BR3215
KEGG:
R01918
MetaCyc:
GSPAMID-RXN
SABIO-RK:
1972
|
|
|
|
gamma-Glu-L-Cys <=> 5-oxoproline + L-cysteine
|
4.3.2.9
gamma-glutamylcyclotransferase
|
–
|
| |
BRENDA:
BS321706
KEGG:
R02743
|
|
|
|
tryparedoxin + ROOH <=> Tryparedoxin_disulfide + H2O + rhodopsin
|
1.11.1
|
–
|
| |
KEGG:
R08360
|
|
|
|
spermidine + glutathione + ATP <=> H+ + glutathionylspermidine + ADP + phosphate
|
6.3.1.8
glutathionylspermidine synthase
6.3.1.9
trypanothione synthase
|
–
–
|
| |
BRENDA:
BR99
KEGG:
R01917
MetaCyc:
GSPSYN-RXN
SABIO-RK:
1971
|
|
|
|
trypanothione + Tryparedoxin_disulfide <=> trypanothione_disulfide + tryparedoxin
|
not assigned
|
–
|
| |
KEGG:
R08361
|
|
|
|
Insulin + 2 glutathione <=> reduced_insulin + GSSG
|
1.8.4.2
protein-disulfide reductase (glutathione)
|
–
|
| |
KEGG:
R02824
|
|
|
|
glutathione + ROOH <=> GSSG + H2O + an_alcohol
|
1.11.1.27
glutathione-dependent peroxiredoxin
1.11.1.9
glutathione peroxidase
|
–
–
|
| |
BRENDA:
BR53022
KEGG:
R12578
MetaCyc:
RXN-20693
|
|
|
|
isocitrate + NADP+ <=> 2-oxoglutarate + CO2 + NADPH
|
1.1.1.286
isocitrate---homoisocitrate dehydrogenase
1.1.1.41
isocitrate dehydrogenase (NAD+)
1.1.1.42
isocitrate dehydrogenase (NADP+)
|
–
–
–
|
| |
BRENDA:
BR29305;
BS370920
KEGG:
R00267
MetaCyc:
ISOCITDEH-RXN
SABIO-RK:
14842;
15247;
269
|
|
|
|
glycine + gamma-Glu-L-Cys + ATP <=> glutathione + ADP + phosphate + H+
|
6.3.2.3
glutathione synthase
|
–
|
| |
BRENDA:
BR119
KEGG:
R00497
MetaCyc:
GLUTATHIONE-SYN-RXN
SABIO-RK:
927
|
|
|
|
glutathione <=> Cys-Gly + 5-oxoproline
|
4.3.2.7
glutathione-specific gamma-glutamylcyclotransferase
4.3.2.9
gamma-glutamylcyclotransferase
|
–
–
|
| |
BRENDA:
BR52222
KEGG:
R11861
MetaCyc:
RXN-19024
SABIO-RK:
15394
|
|
|
|
L-glutamate + L-cysteine + ATP <=> gamma-Glu-L-Cys + ADP + phosphate + H+
|
6.3.2.2
glutamate---cysteine ligase
|
–
|
| |
BRENDA:
BR112
KEGG:
R00894
MetaCyc:
GLUTCYSLIG-RXN
SABIO-RK:
1217
|
|
|
|
putrescine + S-adenosylmethioninamine <=> H+ + spermidine + S-methyl-5''-thioadenosine
|
2.5.1.104
N1-aminopropylagmatine synthase
2.5.1.16
spermidine synthase
2.5.1.23
sym-norspermidine synthase
|
–
–
–
|
| |
BRENDA:
BR47664
KEGG:
R01920
MetaCyc:
SPERMIDINESYN-RXN
SABIO-RK:
1974
|
|
|
|
2''-Deoxyribonucleoside_diphosphate + trypanothione_disulfide + H2O <=> NDP + trypanothione
|
1.17.4.1
ribonucleoside-diphosphate reductase
|
–
|
| |
KEGG:
R08364
|
|
|
|
glutathione + H2O2 <=> GSSG + H2O
|
1.11.1.27
glutathione-dependent peroxiredoxin
1.11.1.9
glutathione peroxidase
|
–
–
|
| |
BRENDA:
BR37185
KEGG:
R00274
MetaCyc:
GLUTATHIONE-PEROXIDASE-RXN
SABIO-RK:
376
|
|
|
|
spermidine + S-adenosylmethioninamine <=> H+ + spermine + S-methyl-5''-thioadenosine
|
2.5.1.104
N1-aminopropylagmatine synthase
2.5.1.16
spermidine synthase
2.5.1.22
spermine synthase
2.5.1.23
sym-norspermidine synthase
2.5.1.79
thermospermine synthase
|
–
–
–
–
–
|
| |
BRENDA:
BR44280
KEGG:
R02869
MetaCyc:
SPERMINE-SYNTHASE-RXN
SABIO-RK:
2733
|
|
|
|
beta-D-glucose_6-phosphate + NADP+ <=> 6-phospho-D-glucono-1,5-lactone + NADPH
|
1.1.1.363
glucose-6-phosphate dehydrogenase [NAD(P)+]
1.1.1.47
glucose 1-dehydrogenase [NAD(P)+]
1.1.1.49
glucose-6-phosphate dehydrogenase (NADP+)
|
–
–
–
|
| |
BRENDA:
BS355829;
BS355830
KEGG:
R02736
SABIO-RK:
18
|
|
|
|
trypanothione + H2O <=> glutathione + glutathionylspermidine
|
3.5.1
3.5.1.78
glutathionylspermidine amidase
|
–
–
|
| |
BRENDA:
BS367840
KEGG:
R08350
|
|
|
|
ATP + glutathione + Glutathionylspermine <=> ADP + phosphate + Bis(glutathionyl)spermine
|
6.3.1.9
trypanothione synthase
|
–
|
| |
KEGG:
R08353
|
|
|
|
ascorbate + H2O2 <=> dehydroascorbate + H2O
|
1.11.1.11
L-ascorbate peroxidase
1.11.1.5
cytochrome-c peroxidase
1.11.1.7
peroxidase
|
–
–
–
|
| |
BRENDA:
BS260337
KEGG:
R00644
SABIO-RK:
1027;
1029
|
|
|
|
trypanothione + ROOH <=> trypanothione_disulfide + H2O + rhodopsin
|
1.11.1
|
–
|
| |
KEGG:
R08362
|
|
|
|
6-phosphogluconate + NADP+ <=> D-ribulose_5-phosphate + CO2 + NADPH
|
1.1.1.351
phosphogluconate dehydrogenase [NAD(P)+-dependent, decarboxylating]
1.1.1.44
phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)
|
–
–
|
| |
BRENDA:
BR29307
KEGG:
R01528
MetaCyc:
6PGLUCONDEHYDROG-RXN;
RXN-9952
|
|
|
|
glutathione + H2O <=> Cys-Gly + L-glutamate
|
2.3.2.2
gamma-glutamyltransferase
3.4.19.13
glutathione gamma-glutamate hydrolase
3.5.1.93
glutaryl-7-aminocephalosporanic-acid acylase
|
–
–
–
|
| |
BRENDA:
BR49838
KEGG:
R00494
MetaCyc:
RXN-12618
SABIO-RK:
926
|
|
|
|
ATP + glutathione + aminopropylcadaverine <=> ADP + phosphate + Glutathionylaminopropylcadaverine
|
6.3.1.9
trypanothione synthase
|
–
|
| |
KEGG:
R08354
|
|
|
|
2''-Deoxyribonucleoside_diphosphate + Tryparedoxin_disulfide + H2O <=> NDP + tryparedoxin
|
1.17.4.1
ribonucleoside-diphosphate reductase
|
–
|
| |
KEGG:
R08363
|
|
|
|
5-oxoproline + H2O + ATP <=> H+ + L-glutamate + phosphate + ADP
|
3.5.2.9
5-oxoprolinase (ATP-hydrolysing)
|
–
|
| |
BRENDA:
BR22721
KEGG:
R00251
MetaCyc:
5-OXOPROLINASE-ATP-HYDROLYSING-RXN
SABIO-RK:
759;
8623
|
|
|
|
thiosulfate + glutathione <=> H+ + sulfite + Sulfide + GSSG
|
2.8.1.3
thiosulfate---thiol sulfurtransferase
|
–
|
| |
BRENDA:
BR48101
KEGG:
R01875
MetaCyc:
THIOSULFATE--THIOL-SULFURTRANSFERASE-RXN
|
|
|
|
L-cystine + glutathione <=> GSSG + L-cysteine
|
1.8.1.6
cystine reductase
1.8.4.4
glutathione---cystine transhydrogenase
1.8.4.9
adenylyl-sulfate reductase (glutathione)
|
–
–
–
|
| |
BRENDA:
BR37026
KEGG:
R01109;
R01113
MetaCyc:
1.8.4.4-RXN
|
|
|
|
ATP + glutathione + Glutathionylaminopropylcadaverine <=> ADP + phosphate + Homotrypanothione
|
6.3.1.9
trypanothione synthase
|
–
|
| |
KEGG:
R08355
|
|
|
|
glutathione + lipid_hydroperoxide <=> GSSG + Lipid + H2O
|
1.11.1.12
phospholipid-hydroperoxide glutathione peroxidase
|
–
|
| |
BRENDA:
BS260442;
BS402670
KEGG:
R03167
|
|
|
|
RS-CH2-CH(NH3+)COO- + acetyl-CoA <=> an_N-acetyl_L-cysteine-S-conjugate + CoA + H+
|
2.3.1.80
cysteine-S-conjugate N-acetyltransferase
|
–
|
| |
BRENDA:
BR44083
KEGG:
R04950
MetaCyc:
2.3.1.80-RXN
SABIO-RK:
3950
|
|
|
|
trypanothione + dehydroascorbate <=> trypanothione_disulfide + ascorbate
|
not assigned
|
–
|
| |
KEGG:
R08358
|
|
|
|
R-S-glutathione + H2O <=> an_(L-cysteinylglycine)-S-conjugate + L-glutamate
|
2.3.2.2
gamma-glutamyltransferase
3.4.19.13
glutathione gamma-glutamate hydrolase
|
–
–
|
| |
BRENDA:
BR52698
KEGG:
R03916
MetaCyc:
RXN-6641
|
|
|
|
Bis(glutathionyl)spermine + NADP+ <=> Bis(glutathionyl)spermine_disulfide + NADPH + H+
|
1.8.1.12
trypanothione-disulfide reductase
|
–
|
| |
KEGG:
R08356
|
|
|
|
glutathione + NADP+ <=> GSSG + NADPH + H+
|
1.8.1.7
glutathione-disulfide reductase
1.8.1.9
thioredoxin-disulfide reductase
1.8.1.B1
1.8.4.2
protein-disulfide reductase (glutathione)
|
–
–
–
–
|
| |
BRENDA:
BR37011
KEGG:
R00115
MetaCyc:
GLUTATHIONE-REDUCT-NADPH-RXN
SABIO-RK:
695
|
|
|
|
cadaverine + S-adenosylmethioninamine <=> H+ + aminopropylcadaverine + S-methyl-5''-thioadenosine
|
2.5.1
2.5.1.104
N1-aminopropylagmatine synthase
2.5.1.16
spermidine synthase
|
–
–
–
|
| |
BRENDA:
BS356253
KEGG:
R08359
MetaCyc:
RXN0-5217
SABIO-RK:
14104
|
|
|
|
O2 + glutathione <=> GSSG + H2O2
|
1.8.3.2
thiol oxidase
1.8.3.3
glutathione oxidase
|
–
–
|
| |
BRENDA:
BR37015
KEGG:
R00120
MetaCyc:
GLUTATHIONE-OXIDASE-RXN
|
|
|
|
2 glutathione + protein_disulfide <=> GSSG + protein-dithiol
|
1.8.4.2
protein-disulfide reductase (glutathione)
|
–
|
| |
BRENDA:
BR37013
KEGG:
R03915
|
|
|
|
pyrimidodiazepine + GSSG + H2O <=> 6-pyruvoyltetrahydropterin + glutathione
|
1.5.4.1
pyrimidodiazepine synthase
|
–
|
| |
BRENDA:
BR40353
KEGG:
R03984
MetaCyc:
1.5.4.1-RXN
|
|
|
|
[Xanthine_dehydrogenase] + GSSG <=> [xanthine_oxidase] + 2 glutathione
|
1.8.4.7
enzyme-thiol transhydrogenase (glutathione-disulfide)
|
–
|
| |
BRENDA:
BR37007
KEGG:
R04039
|
|
|
|
H+ + L-ornithine <=> CO2 + putrescine
|
4.1.1.17
ornithine decarboxylase
4.1.1.18
lysine decarboxylase
4.1.1.19
arginine decarboxylase
4.1.1.86
diaminobutyrate decarboxylase
4.1.1.B12
|
–
–
–
–
–
|
| |
BRENDA:
BR277
KEGG:
R00670
MetaCyc:
ORNDECARBOX-RXN
SABIO-RK:
1050
|
|
|
|
Homotrypanothione + H2O <=> glutathione + Glutathionylaminopropylcadaverine
|
3.5.1
|
–
|
| |
KEGG:
R08351
|
|
|
|
Cys-Gly + H2O <=> L-cysteine + glycine
|
3.4.11.1
leucyl aminopeptidase
3.4.11.10
bacterial leucyl aminopeptidase
3.4.11.2
membrane alanyl aminopeptidase
3.4.11.23
PepB aminopeptidase
3.4.11.6
aminopeptidase B
3.4.13
3.4.13.18
cytosol nonspecific dipeptidase
3.4.13.23
cysteinylglycine-S-conjugate dipeptidase
|
–
–
–
–
–
–
–
–
|
| |
BRENDA:
BS364761
KEGG:
R00899
MetaCyc:
RXN-6622
SABIO-RK:
1221
|
|
|
|
glutathione + glutathionylspermidine + ATP <=> H+ + trypanothione + ADP + phosphate
|
6.3.1.9
trypanothione synthase
|
–
|
| |
BRENDA:
BR48737;
BS427492
KEGG:
R03822
MetaCyc:
6.3.1.9-RXN
SABIO-RK:
3578
|
|
|
|
gamma-glutamyl-L-alanine <=> an_L-amino_acid + 5-oxoproline
|
4.3.2.9
gamma-glutamylcyclotransferase
|
–
|
| |
BRENDA:
BR44112;
BS321692
KEGG:
R03749
MetaCyc:
GAMMA-GLUTAMYLCYCLOTRANSFERASE-RXN
|
|
